GFR is the best overall index of kidney function in health and disease
The normal GFR in young adults is approximately 125 ml/min/1.73 m2
GFR <15 ml/min/1.73 m2 is defined as kidney failure
Can be detected by current estimating equations for GFR based on serum creatinine or cystatin C (estimated GFR) but not by serum creatinine or cystatin Calone
Decreased eGFR can be confirmed by measured GFR, if required
CKD is associated with a wide range of complications
Recent epidemiologic studies have linked decreased GFR and albuminuria to the risk of adverse health outcomes not previously identified as CKD complications.